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In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

Low-protein diet or nutritional therapy in chronic kidney disease

BabaYSonodaJHayashiSTosujiNSonodaSMakisumiKet al

However, individual experiences vary, and some people do develop skin reactions that warrant medical attention

Curr Opin Pharmacol

from Germany, in 2025, examined the oral intake of bovine-derived collagen peptides called GELITA on dermal matrix synthesis and clinical skin parameters in a randomized, double-blind, placebo-controlled trial of 66 women (aged 3555 years) [54]